*Studies/ References**
References
- 1 Zhi-Hong Yang, Hiroko Miyahara , Akimasa Hatanaka. ”Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes”. https://pubmed.ncbi.nlm.nih.gov/21774832/
- 2 Domenico Tricò. “Circulating palmitoleic acid is an independent determinant of insulin sensitivity, beta cell function and glucose tolerance in non-diabetic individuals: a longitudinal analysis”. https://pubmed.ncbi.nlm.nih.gov/31676981/
- 3 K Maedler. “Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function”. https://pubmed.ncbi.nlm.nih.gov/11147797/
- 4 Susan K Duckett.” Palmitoleic acid reduces intramuscular lipid and restores insulin sensitivity in obese sheep”. https://pmc.ncbi.nlm.nih.gov/articles/PMC4243576/
- 5 Chavaro-Ortíz, I. Lidia, et al. “Trans-Palmitoleic Acid Reduces Adiposity Via Increased Lipolysis in a Rodent Model of Diet-Induced Obesity.” Br. J Nutr., May 2021, https://pubmed.ncbi.nlm.nih.gov/33958011/
- 6 Ismail Çimen.” Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation”. https://pubmed.ncbi.nlm.nih.gov/27683551/
- 7 Cunningham, Eleese, RDN. “What Are n-7 Fatty Acids and Are There Health Benefits Associated with Them?” Journal of the Academy of Nutrition and Dietetics, January 2015, https://www.jandonline.org/article/S2212-2672(14)01769-9/fulltext#relatedArticles
- 8 Di Pasquale, G. Mauro. “The Essentials of Essential Fatty Acids.” J Diet Suppl., 2009, https://pubmed.ncbi.nlm.nih.gov/22435414/
- 9 Frigolet, E. María et al. “The Role of the Novel Lipokine Palmitoleic Acid in Health and Disease.” Adv Nutr., January 2017, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5227969/
- 10 Hu, Wei et al. “A Review of Biological Functions, Health Benefits, and Possible de Novo Biosynthetic Pathway of Palmitoleic Acid in Macadamia nuts.” Journal of Functional Foods, November 2019, https://www.sciencedirect.com/science/article/
- 11 Morris, J.; Sampalis, T. Evaluation of the effects of Provinal® on the management of Dry Eye Syndrome. Unpublished.
- 12 Rafael Sánchez-Borrego. “Highly concentrated palmitoleic acid proving the safety and efficacy of Provinal® for cardiometabolic disorders and dry eye syndrome”. https://www.maturitas.org/article/S0378-5122(17)30255-4/
- 13 Kane, B.J. Observational study assessing the effect of Provinal® on Dry Eye Disease. Unpublished
- 14 Kimura, Yuki et al. “Restoration of Tear Secretion in a Murine Dry Eye Model by Oral Administration of Palmitoleic Acid.” Nutrients, April 2017, https://pubmed.ncbi.nlm.nih.gov/28379171/
- 15 Kremmyda, Stella Lefkothea, et. al. “Fatty Acids as Biocompounds: Their Role in Human Metabolism, Health and Disease: A Review. Part 2: Fatty Acid Physiological Roles and Applications in Human Health and Disease.” Biomed Pap Med Fac Univ Palacky Olomjuc Czech Repub., September 2011, https://pubmed.ncbi.nlm.nih.gov/22286806/
- 16 Marsiñach, Solà Marta et al. “The Impact of Sea Buckthorn Oil Fatty Acids on Human Health.” Lipids Health Dis. June 2019. https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6589177/
- 17 Nallely Bueno-Hernández. “Effect of Cis-palmitoleic acid supplementation on inflammation and expression of HNF4γ, HNF4α and IL6 in patients with ulcerative colitis”. https://pubmed.ncbi.nlm.nih.gov/28185444/
- 18 Eleine Welmann.” Topical anti-inflammatory activity of palmitoleic acid improves wound healing”. https://pubmed.ncbi.nlm.nih.gov/30307983/
- 19 Dyerberg J, Bang HO, Hjørne N. “Fatty acid composition of the plasma lipids in Greenland Eskimos”. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.0954-6820.1972.tb04782.x
- 20 Camila Oliveira de Souza. “Palmitoleic Acid has Stronger Anti-Inflammatory Potential in Human Endothelial Cells Compared to Oleic and Palmitic Acids”. https://pubmed.ncbi.nlm.nih.gov/30102465/
- 21 Jussara J. Simão.”,Palmitoleic Acid Acts on Adipose-Derived Stromal Cells and Promotes Anti-Hypertrophic and Anti-Inflammatory Effects in Obese Mice”. https://www.mdpi.com/1424-8247/15/10/1194).
- 22 Song, In-Bong, et. al. “Omega-7 Inhibits Inflammation and Promotes Collagen Synthesis Through SIRT1 Activation.” Applied Biological Chemistry, June 2018, https://applbiolchem.springeropen.com/articles/10.1007/s13765-018-0377-1
- 23 Tall, R. Alan, et al. “Cholesterol, Inflammation and Innate Immunity.” Nat Rev Immunol., February 2015, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4669071/
- 24 Weimann, Eleine, et al. “Topical Anti-Inflammatory Activity of Palmitoleic Acid Improves Wound Healing.” PLoS One, October 2018, https://pubmed.ncbi.nlm.nih.gov/30307983/
- 25 Yang, Zhi-Hong, Jiro, Takeo, Masashi Katayama. “Oral Administration of Omega-7 Palmitoleic Acid Induces Satiety and the Release of Appetite-Related Hormones in Male Rats.” Appetite, June 2013, https://pubmed.ncbi.nlm.nih.gov/23376733/
- 26 Young Gue Koh. “Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study”, PMCID: PMC10245245 PMID: 37292315
- 27 Bolsoni-Lopes et al. “ Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation”. Lipids in Health and Disease 2014, 13:199, http://www.lipidworld.com/content/13/1/199
- 28 Passos, M.E.P., Alves, H.H.O., Momesso, C.M. et al. Differential effects of palmitoleic acid on human lymphocyte proliferation and function. Lipids Health Dis 15, 217 (2016). https://doi.org/10.1186/s12944-016-0385-2
- 29 Koh YG, Seok J, Park JW, Kim KR, Yoo KH, Kim YJ, Kim BJ. Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study. Heliyon. 2023 May 26;9(6):e16711. doi: 10.1016/j.heliyon.2023.e16711. PMID: 37292315; PMCID: PMC10245245. https://pubmed.ncbi.nlm.nih.gov/37292315/
- 30 Guo X, Jiang X, Chen K, et al. The Role of Palmitoleic Acid in Regulating Hepatic Gluconeogenesis through SIRT3 in Obese Mice. Nutrients. 2022;14(7):1482-1482. doi: https://doi.org/10.3390/nu14071482
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